____ course of time, he became a famous writer.

In

Of

For

By

Explanation:

Correct Answer is: In
এখানে in course of time এর বাংলা অর্থ হলো – কালক্রমে ,সময়ের সাথে সাথে,কালে; শেষপর্যন্ত; অবশেষে। অর্থাৎ as time passes.
example:
In course of time, he became a famous writer.
Things will get better in the course of time.
In the course of time, people learned to accept the changes.
 
 SOURCE: A Passage To The English Language by S. M. Zakir Hussain

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